Mechanism of Collagen Remodeling

 

BEFORE

§Collagen has high density with small intrafibrilar

 spacing that prevents growth of new fibers and

 limits the blood supply.

 

IMMEDIATELY AFTER

 

 

§Deep edema, intrafibrilar spacing is increased due

to release of liquids from lymphatic and vascular

 systems.

 

§Fibers are separated and oriented chaotically.

 

§Edema and erythema appear.

 

3- WEEKS AFTER

 

§After edema decreases the collagen maintains

 enlarged intrafibrilar spacing which is filled with

 new collagen.

 

SIDE BY SIDE COMPARISON

BEFORE                                                3-WEEKS AFTER